Which class of medications is often prescribed for the management of menopausal symptoms?

• A. Selective serotonin reuptake inhibitors (SSRIs)
• B. Antidepressants
• C. Hormone Replacement Therapy (HRT)
• D. Non-steroidal anti-inflammatory drugs (NSAIDs)

Answer: (C)

Hormone Replacement Therapy (HRT) is the standard treatment for managing menopausal symptoms, primarily hot flashes, night sweats, and vaginal dryness. HRT works by supplementing the body with estrogen and, in some cases, progesterone, compensating for the hormonal fluctuations and reductions that occur during menopause. This therapy effectively alleviates many of the discomforts associated with menopause, providing relief and improving the quality of life for many women.

The rationale for using HRT includes its ability to address the root cause of menopausal symptoms, which result from decreased estrogen levels. This medication class can also offer long-term benefits, such as reduced risk of osteoporosis and improved cardiovascular health when initiated in younger postmenopausal women.

While other classes of medications like SSRIs and antidepressants may help alleviate some psychological symptoms associated with menopause, such as mood swings or depression, they do not specifically target the primary physiological symptoms like hot flashes or vaginal atrophy. Similarly, NSAIDs primarily serve to relieve pain and inflammation rather than address hormonal imbalances or menopausal symptoms directly.