Women with polycystic ovarian syndrome (PCOS) abnormally metabolize:

• A. Progesterone and luteinizing hormone
• B. Progesterone and estrogen
• C. Luteinizing hormone and androgen
• D. Androgens and estrogen

Answer: (D)

In polycystic ovarian syndrome (PCOS), women commonly exhibit an abnormal metabolism of androgens and estrogen. PCOS is characterized by an imbalance in sex hormones, leading to elevated levels of androgens, such as testosterone. This increased androgen production is a crucial element of the condition and contributes to various symptoms like hirsutism, acne, and menstrual irregularities.

Additionally, estrogen metabolism can be altered in PCOS. The increased levels of androgens can lead to increased conversion to estrogen through peripheral aromatization. This imbalance can contribute to anovulation and other reproductive issues commonly seen in women with PCOS.

Understanding the abnormal metabolism of these hormones is essential when addressing the clinical manifestations of the syndrome and in considering therapeutic options. It highlights the interconnectedness of hormonal regulation and the complexities involved in managing PCOS effectively.